Short answer: No, steroid injections do not usually cause weight gain.
Many patients worry about side effects, and weight gain is a common concern. Understanding how these injections work can help reassure you and give a clearer idea of what to expect.
Understanding Steroid Injections
Steroid injections used in musculoskeletal care usually contain corticosteroids such as methylprednisolone. These medications are excellent at reducing inflammation and easing pain from arthritis, tendon irritation, or joint issues.
Because the steroid is delivered directly into the affected area, it works where it is needed most. Only a very small amount enters the bloodstream, which greatly reduces the chance of whole-body side effects.
Why Weight Gain Is Unlikely
Weight gain is not a common side effect of local steroid injections.
Unlike oral steroids, which affect the entire body and can influence appetite, metabolism, and fluid balance, local injections deliver medicine directly to the joint or tendon. This targeted approach keeps systemic effects very low.
When Weight Gain Might Occur
Although rare, a few situations could lead to small changes in weight:
- Repeated injections in a short period
- Larger doses of steroid that may influence appetite or cause mild fluid retention
- Individual medical conditions that make someone more sensitive to steroids
Your clinician will always aim to use the lowest effective dose and space injections appropriately to minimise any risk.
Managing Possible Side Effects
To reduce the chance of unwanted effects:
- Avoid frequent injections unless clinically necessary
- Use the smallest dose that still provides meaningful relief
- Maintain a healthy lifestyle with balanced nutrition and regular activity
These steps help keep benefits high and risks low.
Speak With Your Clinician
If you have questions about weight gain or any other side effects, speak with your clinician. We are always happy to provide personalised advice and help you understand the safest, most effective treatment options for your needs.
References
- Wung PK. Effects of glucocorticoids on weight change during the first year of treatment. Journal of Clinical Endocrinology and Metabolism. 2008.
- Savas M et al. Systematic evaluation of corticosteroid use in obese and non-obese individuals. Journal of Clinical Endocrinology and Metabolism. 2017.
- Mohseni M et al. Corticosteroid use and long-term changes in weight and waist circumference. Journal of Clinical Endocrinology and Metabolism. 2025.
- Kulkarni S et al. Metabolic adverse events associated with systemic corticosteroid therapy. BMJ Open. 2022.
Conklin AI et al. Obesity prevention in corticosteroid treated patients. Clinical Obesity. 2019.